About 12:40 a.m., someone emerged from a gangway in the 6300 block of South May Street and opened fire on a moving vehicle.
Two men inside the vehicle were struck and were taken to John H. Stroger, Jr. Hospital of Cook County.
One of them, a 22-year-old man struck multiple times, died at the hospital.
The other man, who is 36, was struck in the shoulder. His condition has been stabilized